We took a retrospective assessment about the relationships to steroid therapy with 12 patients of AVN in SLE, comparing with the control cases which were composed of 25 patients of SLE followed up more than 5 years but free from evidence of AVN,
who
had been treated at catholic University Medical College from 1986 to 1992. Based on results of above assessment, we carried out comparative analysis of above 2 groups to delineate the statistical significance between AVN and steroid therapy in
SLE
using
Student's t-test, and its each items of statistical analysis were as follows; initial cumulative dosage on 1,3,6 months, average monthly dosage, average monthly dosage of pulse therapy and average monthly dosage of maintenance therapy throughout
follow
up period. In addition, we also reported the author's clinical experience in the orthopaedic management of 12 AVN patients in SLE with a respect of age & sex distribution, interval between diagnosis of SLE and AYN, involvement sites, radiologic
stage
especially in femoral head, treatment method and complication of treatment.
This retrospective study was relatively fragmentary but show that both initial higher steroid therapy and average dosage per months seem to be related with eventual development of AVN in SLE. In addition, the average monthly dosage of pulse
therapy
seems to have an influence on development of AVN in SLE also. But, the more distinct cause of AVN and the role of steroid in SLE may be elucidated through the further prospective attempt with an elaborate plan in concert with medical doctors.
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